260447

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 198..672 Replicon plasmid punamed2
Accession NZ_CP107019
Organism Klebsiella pneumoniae strain K30821

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag OF890_RS29485 Protein ID WP_004197762.1
Coordinates 406..672 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag OF890_RS29480 Protein ID WP_000879771.1
Coordinates 198..422 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF890_RS29480 (OF890_29480) 198..422 + 225 WP_000879771.1 DUF6290 family protein Antitoxin
OF890_RS29485 (OF890_29485) 406..672 + 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OF890_RS29490 (OF890_29490) 742..1092 - 351 WP_004197756.1 hypothetical protein -
OF890_RS29495 (OF890_29495) 1158..1703 - 546 WP_023317533.1 hypothetical protein -
OF890_RS29500 (OF890_29500) 1729..2055 - 327 WP_050516389.1 hypothetical protein -
OF890_RS29505 (OF890_29505) 3211..3387 + 177 WP_004197757.1 hypothetical protein -
OF890_RS29510 (OF890_29510) 3377..3721 + 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
OF890_RS29515 (OF890_29515) 3930..4364 + 435 Protein_7 relaxase/mobilization nuclease domain-containing protein -
OF890_RS29520 (OF890_29520) 4399..4908 + 510 WP_032433972.1 MbeB family mobilization protein -
OF890_RS29525 (OF890_29525) 4915..5127 + 213 WP_021527181.1 MbeD family mobilization/exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T260447 WP_004197762.1 NZ_CP107019:406-672 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT260447 WP_000879771.1 NZ_CP107019:198-422 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References