Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 3758..4338 Replicon plasmid punamed1
Accession NZ_CP107018
Organism Klebsiella pneumoniae strain K30821

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag OF890_RS29440 Protein ID WP_071177730.1
Coordinates 4024..4338 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag OF890_RS29435 Protein ID WP_000093040.1
Coordinates 3758..4036 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF890_RS29415 (OF890_29415) 199..1686 - 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
OF890_RS29420 (OF890_29420) 2331..2576 + 246 WP_032440458.1 hypothetical protein -
OF890_RS29425 (OF890_29425) 2850..3221 + 372 WP_001237044.1 cell envelope integrity protein TolA -
OF890_RS29430 (OF890_29430) 3218..3583 + 366 WP_072354022.1 TonB family protein -
OF890_RS29435 (OF890_29435) 3758..4036 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
OF890_RS29440 (OF890_29440) 4024..4338 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OF890_RS29445 (OF890_29445) 4502..4930 + 429 WP_001140599.1 hypothetical protein -
OF890_RS29450 (OF890_29450) 4956..5135 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
OF890_RS29455 (OF890_29455) 5162..5692 - 531 WP_071177729.1 hypothetical protein -
OF890_RS29460 (OF890_29460) 5699..6430 - 732 WP_071177728.1 MobC family replication-relaxation protein -
OF890_RS29465 (OF890_29465) 6430..8394 - 1965 WP_071177727.1 TraM recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11970 11970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T260446 WP_071177730.1 NZ_CP107018:4024-4338 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT260446 WP_000093040.1 NZ_CP107018:3758-4036 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References