Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /RES-TIGR02293 |
Location | 75819..76729 | Replicon | plasmid pVi-K30821 |
Accession | NZ_CP107015 | ||
Organism | Klebsiella pneumoniae strain K30821 |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A663AYG0 |
Locus tag | OF890_RS27160 | Protein ID | WP_004026354.1 |
Coordinates | 76259..76729 (+) | Length | 157 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A6P1V3Q9 |
Locus tag | OF890_RS27155 | Protein ID | WP_004026357.1 |
Coordinates | 75819..76262 (+) | Length | 148 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OF890_RS27125 (OF890_27125) | 70837..71358 | + | 522 | WP_004213635.1 | ferric citrate uptake sigma factor FecI | - |
OF890_RS27130 (OF890_27130) | 71355..72308 | + | 954 | Protein_82 | fec operon regulator FecR | - |
OF890_RS27135 (OF890_27135) | 72395..74521 | + | 2127 | WP_004213640.1 | TonB-dependent Fe(3+) dicitrate receptor FecA | - |
OF890_RS27140 (OF890_27140) | 74596..74715 | + | 120 | Protein_84 | Fe3+-citrate ABC transporter substrate-binding protein | - |
OF890_RS27145 (OF890_27145) | 74896..75117 | + | 222 | WP_004213643.1 | DUF2188 domain-containing protein | - |
OF890_RS27150 (OF890_27150) | 75215..75718 | + | 504 | Protein_86 | DUF4113 domain-containing protein | - |
OF890_RS27155 (OF890_27155) | 75819..76262 | + | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
OF890_RS27160 (OF890_27160) | 76259..76729 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
OF890_RS27165 (OF890_27165) | 76878..77575 | + | 698 | WP_223175001.1 | IS1-like element IS1A family transposase | - |
OF890_RS27170 (OF890_27170) | 77577..78026 | + | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
OF890_RS27175 (OF890_27175) | 78043..78354 | + | 312 | WP_011251282.1 | hypothetical protein | - |
OF890_RS27180 (OF890_27180) | 78368..78709 | + | 342 | WP_011251281.1 | hypothetical protein | - |
OF890_RS27185 (OF890_27185) | 78769..79725 | + | 957 | WP_011251280.1 | DsbA family protein | - |
OF890_RS27190 (OF890_27190) | 80150..80590 | - | 441 | WP_011251275.1 | hypothetical protein | - |
OF890_RS27195 (OF890_27195) | 80596..81090 | - | 495 | WP_011251274.1 | hypothetical protein | - |
OF890_RS27200 (OF890_27200) | 81099..81413 | - | 315 | WP_011251273.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | - | rmpA2 / iutA / iucD / iucC / iucB / iucA / rmpA / iroN / iroD / iroC / iroB | 1..237143 | 237143 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T260434 WP_004026354.1 NZ_CP107015:76259-76729 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT260434 WP_004026357.1 NZ_CP107015:75819-76262 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A663AYG0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6P1V3Q9 |