Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4733912..4734722 Replicon chromosome
Accession NZ_CP107014
Organism Klebsiella pneumoniae strain K30821

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag OF890_RS23535 Protein ID WP_002887280.1
Coordinates 4733912..4734445 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag OF890_RS23540 Protein ID WP_002887278.1
Coordinates 4734456..4734722 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF890_RS23530 (OF890_23530) 4732743..4733864 + 1122 WP_002887282.1 cupin domain-containing protein -
OF890_RS23535 (OF890_23535) 4733912..4734445 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
OF890_RS23540 (OF890_23540) 4734456..4734722 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
OF890_RS23545 (OF890_23545) 4734825..4736258 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
OF890_RS23550 (OF890_23550) 4736248..4736931 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
OF890_RS23555 (OF890_23555) 4737103..4738488 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
OF890_RS23560 (OF890_23560) 4738506..4738850 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T260429 WP_002887280.1 NZ_CP107014:c4734445-4733912 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT260429 WP_002887278.1 NZ_CP107014:c4734722-4734456 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References