Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 7068..7615 Replicon plasmid pSZB23-1
Accession NZ_CP107011
Organism Salmonella enterica subsp. enterica serovar Paratyphi B strain SZ21B23

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag OF884_RS22625 Protein ID WP_244442846.1
Coordinates 7337..7615 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag OF884_RS22620 Protein ID WP_000079941.1
Coordinates 7068..7337 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF884_RS22595 (2509) 2509..3717 - 1209 WP_000198533.1 IS91 family transposase -
OF884_RS22600 (3698) 3698..3970 - 273 WP_000019163.1 hypothetical protein -
OF884_RS22605 (4185) 4185..5000 + 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -
OF884_RS22610 (5087) 5087..5329 + 243 Protein_4 phosphoglucosamine mutase -
OF884_RS22615 (5565) 5565..6710 - 1146 Protein_5 IS91-like element ISVsa3 family transposase -
OF884_RS22620 (7068) 7068..7337 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
OF884_RS22625 (7337) 7337..7615 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
OF884_RS22630 (7655) 7655..8503 + 849 WP_021265674.1 3'-5' exonuclease -
OF884_RS22635 (8620) 8620..9093 + 474 WP_001334658.1 hypothetical protein -
OF884_RS22640 (9570) 9570..9836 - 267 WP_000955263.1 hypothetical protein -
OF884_RS22645 (9836) 9836..10330 - 495 WP_001459505.1 hypothetical protein -
OF884_RS22650 (10386) 10386..10988 - 603 WP_000517695.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul2 / blaCTX-M-14 - 1..97817 97817


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T260414 WP_244442846.1 NZ_CP107011:7337-7615 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT260414 WP_000079941.1 NZ_CP107011:7068-7337 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References