Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4017482..4018032 Replicon chromosome
Accession NZ_CP107010
Organism Salmonella enterica subsp. enterica serovar Paratyphi B strain SZ21B23

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag OF884_RS19435 Protein ID WP_001199743.1
Coordinates 4017482..4017790 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag OF884_RS19440 Protein ID WP_000016244.1
Coordinates 4017793..4018032 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF884_RS19425 (4012901) 4012901..4016416 - 3516 WP_000342546.1 AAA domain-containing protein -
OF884_RS19430 (4016778) 4016778..4017061 - 284 Protein_3802 Arm DNA-binding domain-containing protein -
OF884_RS19435 (4017482) 4017482..4017790 - 309 WP_001199743.1 CcdB family protein Toxin
OF884_RS19440 (4017793) 4017793..4018032 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
OF884_RS19445 (4018145) 4018145..4018393 - 249 WP_000168387.1 ribbon-helix-helix domain-containing protein -
OF884_RS19450 (4018584) 4018584..4019015 - 432 Protein_3806 helix-turn-helix domain-containing protein -
OF884_RS19460 (4019773) 4019773..4020792 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
OF884_RS19465 (4020820) 4020820..4021350 - 531 WP_000896756.1 gluconokinase -
OF884_RS19470 (4021567) 4021567..4022598 + 1032 WP_000453341.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4018470..4018970 500


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T260410 WP_001199743.1 NZ_CP107010:c4017790-4017482 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT260410 WP_000016244.1 NZ_CP107010:c4018032-4017793 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References