Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3975498..3976074 Replicon chromosome
Accession NZ_CP107010
Organism Salmonella enterica subsp. enterica serovar Paratyphi B strain SZ21B23

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag OF884_RS19260 Protein ID WP_001131963.1
Coordinates 3975787..3976074 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag OF884_RS19255 Protein ID WP_000063143.1
Coordinates 3975498..3975800 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF884_RS19240 (3972008) 3972008..3974158 + 2151 WP_000379929.1 pyruvate/proton symporter BtsT -
OF884_RS19245 (3974253) 3974253..3974456 + 204 WP_000460616.1 YbdD/YjiX family protein -
OF884_RS19250 (3974467) 3974467..3975423 + 957 WP_000187838.1 GTPase -
OF884_RS19255 (3975498) 3975498..3975800 - 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
OF884_RS19260 (3975787) 3975787..3976074 - 288 WP_001131963.1 BrnT family toxin Toxin
OF884_RS19265 (3976343) 3976343..3977257 - 915 WP_000290513.1 restriction endonuclease -
OF884_RS19270 (3977455) 3977455..3980964 + 3510 WP_023210401.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T260409 WP_001131963.1 NZ_CP107010:c3976074-3975787 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT260409 WP_000063143.1 NZ_CP107010:c3975800-3975498 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References