Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3379464..3380084 Replicon chromosome
Accession NZ_CP107010
Organism Salmonella enterica subsp. enterica serovar Paratyphi B strain SZ21B23

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag OF884_RS16515 Protein ID WP_001280991.1
Coordinates 3379866..3380084 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag OF884_RS16510 Protein ID WP_000344807.1
Coordinates 3379464..3379838 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF884_RS16500 (3374603) 3374603..3375796 + 1194 WP_001039200.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OF884_RS16505 (3375819) 3375819..3378968 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
OF884_RS16510 (3379464) 3379464..3379838 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
OF884_RS16515 (3379866) 3379866..3380084 + 219 WP_001280991.1 HHA domain-containing protein Toxin
OF884_RS16520 (3380262) 3380262..3380813 + 552 WP_001278791.1 maltose O-acetyltransferase -
OF884_RS16525 (3380931) 3380931..3381401 + 471 WP_000136181.1 YlaC family protein -
OF884_RS16530 (3381457) 3381457..3381597 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
OF884_RS16535 (3381603) 3381603..3381863 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
OF884_RS16540 (3382088) 3382088..3383638 + 1551 WP_000213139.1 EAL domain-containing protein -
OF884_RS16550 (3383869) 3383869..3384258 + 390 WP_000961285.1 MGMT family protein -
OF884_RS16555 (3384291) 3384291..3384860 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T260408 WP_001280991.1 NZ_CP107010:3379866-3380084 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT260408 WP_000344807.1 NZ_CP107010:3379464-3379838 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References