Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 842693..843318 Replicon chromosome
Accession NZ_CP107010
Organism Salmonella enterica subsp. enterica serovar Paratyphi B strain SZ21B23

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OF884_RS04075 Protein ID WP_000911337.1
Coordinates 842920..843318 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3R8TS06
Locus tag OF884_RS04070 Protein ID WP_000557548.1
Coordinates 842693..842920 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF884_RS04040 (837738) 837738..839255 + 1518 WP_000003339.1 lysine--tRNA ligase -
OF884_RS04045 (839331) 839331..839876 - 546 WP_000133985.1 isopentenyl-diphosphate Delta-isomerase -
OF884_RS04050 (840141) 840141..840899 + 759 WP_000244330.1 amidase activator ActS -
OF884_RS04060 (841184) 841184..841990 - 807 WP_077905557.1 DUF1460 domain-containing protein -
OF884_RS04065 (842265) 842265..842516 - 252 WP_001540858.1 hypothetical protein -
OF884_RS04070 (842693) 842693..842920 + 228 WP_000557548.1 toxin-antitoxin system antitoxin VapB Antitoxin
OF884_RS04075 (842920) 842920..843318 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
OF884_RS04080 (844126) 844126..844662 + 537 WP_001038502.1 STM3031 family outer membrane protein -
OF884_RS04085 (844709) 844709..845341 + 633 WP_000835265.1 YfdX family protein -
OF884_RS04090 (846060) 846060..846644 + 585 WP_001244635.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 842265..851104 8839


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T260401 WP_000911337.1 NZ_CP107010:842920-843318 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8530.55 Da        Isoelectric Point: 5.0210

>AT260401 WP_000557548.1 NZ_CP107010:842693-842920 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQLAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8TS06

References