Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 831806..832466 Replicon chromosome
Accession NZ_CP107010
Organism Salmonella enterica subsp. enterica serovar Paratyphi B strain SZ21B23

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I5GR00
Locus tag OF884_RS04010 Protein ID WP_000244761.1
Coordinates 832053..832466 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag OF884_RS04005 Protein ID WP_000351186.1
Coordinates 831806..832072 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF884_RS03985 (827735) 827735..829168 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
OF884_RS03990 (829326) 829326..829637 + 312 WP_023210126.1 N(4)-acetylcytidine aminohydrolase -
OF884_RS03995 (829801) 829801..830460 + 660 WP_000250289.1 hemolysin III family protein -
OF884_RS04000 (830576) 830576..831556 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
OF884_RS04005 (831806) 831806..832072 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
OF884_RS04010 (832053) 832053..832466 + 414 WP_000244761.1 protein YgfX Toxin
OF884_RS04015 (832519) 832519..833040 - 522 WP_001055885.1 flavodoxin FldB -
OF884_RS04020 (833153) 833153..834049 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
OF884_RS04025 (834073) 834073..834786 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OF884_RS04030 (834792) 834792..836525 + 1734 WP_000813379.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16199.15 Da        Isoelectric Point: 10.7537

>T260400 WP_000244761.1 NZ_CP107010:832053-832466 [Salmonella enterica subsp. enterica serovar Paratyphi B]
VVLWQSDLRVSWRAQWISLLIHGLVSAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT260400 WP_000351186.1 NZ_CP107010:831806-832072 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5GR00

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References