Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2563772..2565437 Replicon chromosome
Accession NZ_CP107009
Organism Halomonas sp. LR3S48

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OCT51_RS12050 Protein ID WP_263580087.1
Coordinates 2563772..2565118 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OCT51_RS12055 Protein ID WP_263580088.1
Coordinates 2565132..2565437 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCT51_RS12035 (OCT51_12035) 2559923..2561344 + 1422 WP_263580084.1 FAD-binding oxidoreductase -
OCT51_RS12040 (OCT51_12040) 2561410..2561919 + 510 WP_263580085.1 CAP domain-containing protein -
OCT51_RS12045 (OCT51_12045) 2562719..2563618 + 900 WP_263580086.1 nucleotidyltransferase domain-containing protein -
OCT51_RS12050 (OCT51_12050) 2563772..2565118 + 1347 WP_263580087.1 HipA domain-containing protein Toxin
OCT51_RS12055 (OCT51_12055) 2565132..2565437 + 306 WP_263580088.1 helix-turn-helix transcriptional regulator Antitoxin
OCT51_RS12060 (OCT51_12060) 2565517..2566311 - 795 WP_263580089.1 glycosyltransferase -
OCT51_RS12065 (OCT51_12065) 2566514..2567581 + 1068 WP_263580090.1 glycosyltransferase -
OCT51_RS12070 (OCT51_12070) 2567655..2568359 + 705 WP_263580091.1 lipopolysaccharide kinase InaA family protein -
OCT51_RS12075 (OCT51_12075) 2568423..2569541 - 1119 WP_263580092.1 glycosyltransferase -
OCT51_RS12080 (OCT51_12080) 2569525..2570334 - 810 WP_263580093.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-392)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-88)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 50705.18 Da        Isoelectric Point: 5.5715

>T260398 WP_263580087.1 NZ_CP107009:2563772-2565118 [Halomonas sp. LR3S48]
MQLTIQIYHDQRWQDAALLDIPDPERGVHGAAELSYLQDYAIDWLFHDDEHACSLTLPVELMMKHRAERWFGFLEDIMPA
GASRRYWVTHLGMQGTSAGEQDSALLRHGTIAPVGNLRIKEALPQRLAGSRLEAHRFTLQDVVERHADFLEYAQQMGAAS
GGATGAGGEAPKLLLRRTTDNKVWIDTWQDDPGNHDRAYLVKFPRGQRSQDDCDILRAEYHYYQELAALGIDTIDTGAMQ
LIEGERYPSLWLPRFDISMHENGQARFGLESIYAIFGAAPGAHLNHFQVIRGLVERLERQNRVTQGKQPFDTAAFVSEWV
KRDLLNVAFGNSDNHGRNAALLKRPEGIWHAPVYDFAPMKADPEGVTRTTRWGSPFEEGGEFDWQAIAEQLNDLAPAPQL
MQELRTLAGQLVGLQERLRERGVPERILTMPAVGLNTLEDRLKRWSLL

Download         Length: 1347 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11709.61 Da        Isoelectric Point: 10.8054

>AT260398 WP_263580088.1 NZ_CP107009:2565132-2565437 [Halomonas sp. LR3S48]
MKKRELTPDEREQKLLDVARQLLTEEISEGQALRILRRDVLGLSQDAYAKLVGISRRTLSDLERNRANMTLDAMNRVYRP
LGLRVGLLPRQRALLERALEQ

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References