Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 255160..255809 Replicon chromosome
Accession NZ_CP107009
Organism Halomonas sp. LR3S48

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OCT51_RS01160 Protein ID WP_263583899.1
Coordinates 255160..255357 (+) Length 66 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OCT51_RS01165 Protein ID WP_263582090.1
Coordinates 255396..255809 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCT51_RS01145 (OCT51_01145) 252121..252618 + 498 WP_263582087.1 contact-dependent growth inhibition system immunity protein -
OCT51_RS01150 (OCT51_01150) 252823..254604 + 1782 WP_263582088.1 DUF637 domain-containing protein -
OCT51_RS01155 (OCT51_01155) 254604..254972 + 369 WP_263582089.1 hypothetical protein -
OCT51_RS01160 (OCT51_01160) 255160..255357 + 198 WP_263583899.1 type II toxin-antitoxin system HicA family toxin Toxin
OCT51_RS01165 (OCT51_01165) 255396..255809 + 414 WP_263582090.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OCT51_RS01170 (OCT51_01170) 255889..257397 - 1509 WP_263582091.1 MFS transporter -
OCT51_RS01175 (OCT51_01175) 257453..257911 - 459 WP_263582092.1 universal stress protein -
OCT51_RS01180 (OCT51_01180) 257981..259612 - 1632 WP_263582093.1 antiporter -
OCT51_RS01185 (OCT51_01185) 259897..260565 - 669 WP_263582094.1 two-component system response regulator NarL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(16-64)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7486.64 Da        Isoelectric Point: 10.7164

>T260396 WP_263583899.1 NZ_CP107009:255160-255357 [Halomonas sp. LR3S48]
MAWGYYNPKERGKEPEADGWTLDRVKGSHHHFRHPYKPGTITVPHPKKDLKKGLIQGIRKQAGLK

Download         Length: 198 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14946.79 Da        Isoelectric Point: 5.1469

>AT260396 WP_263582090.1 NZ_CP107009:255396-255809 [Halomonas sp. LR3S48]
MHYPIAIEVGDEQHAYGVVVPDLPGCFSAGDTFDGAIANAREAIEGHLESLAEHGDPIPTATAIQQHLENPDFAGWIWAA
VEIDMTPYLGKSHKINVTLPDLLIKRIDSTVAKHGDYKSRSGFLARAALHELERHAQ

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References