Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1941108..1942801 Replicon chromosome
Accession NZ_CP107008
Organism Halomonas sp. M4R1S46

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OCT48_RS09175 Protein ID WP_263592384.1
Coordinates 1941422..1942801 (-) Length 460 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OCT48_RS09170 Protein ID WP_263592383.1
Coordinates 1941108..1941425 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCT48_RS09160 (OCT48_09160) 1936742..1937971 + 1230 WP_263592381.1 HlyD family efflux transporter periplasmic adaptor subunit -
OCT48_RS09165 (OCT48_09165) 1937968..1941102 + 3135 WP_263592382.1 efflux RND transporter permease subunit -
OCT48_RS09170 (OCT48_09170) 1941108..1941425 - 318 WP_263592383.1 helix-turn-helix domain-containing protein Antitoxin
OCT48_RS09175 (OCT48_09175) 1941422..1942801 - 1380 WP_263592384.1 HipA domain-containing protein Toxin
OCT48_RS09180 (OCT48_09180) 1942897..1943559 + 663 WP_263592385.1 SDR family oxidoreductase -
OCT48_RS09185 (OCT48_09185) 1943681..1944493 - 813 WP_263592386.1 formate/nitrite transporter family protein -
OCT48_RS09190 (OCT48_09190) 1944774..1945082 + 309 WP_263592387.1 hypothetical protein -
OCT48_RS09195 (OCT48_09195) 1945311..1946900 + 1590 WP_263592388.1 peptide chain release factor 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(176-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 460 a.a.        Molecular weight: 51745.87 Da        Isoelectric Point: 6.3065

>T260395 WP_263592384.1 NZ_CP107008:c1942801-1941422 [Halomonas sp. M4R1S46]
MSIILLTESSMQLTIQIYRQGRWQDAARLELPHPERGTRGPARLGYLQDYALQWMSHDDEHACSLTLPVELMMRHHGERW
FGFLEDIMPAGASRRYWIQHLGIQDLAPGEQDTELLRLGTIAPVGNLRIREAVPPRPPGGTLEAQRFPLSDVIDRHTDFL
EYAQQMGAASGGATGAGGEAPKLLVRRTPGDEVWIDTWQDDPTNLDPHFLVKFPRGRRGADDCDILRAEYHYYRELAELG
IDTVPRQGLQLTEGERYPSLWLPRFDVAPREGRLCRFGLESVYALLGVAPGTHLRHPAVLARLVALLERQHRVRELGEPF
DREGFVIEWVRRDLLNVAFGNSDNHGRNAALLKRPEGIWHAPVYDFAPMKADPEGVTRTTQWGPPLEQGGDFDWPAIARS
LGELADPDRLMAELERLGARLHGLAERLAARGVPERILTMPAVGLGHLDRRLTRWGLAP

Download         Length: 1380 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11606.41 Da        Isoelectric Point: 10.3451

>AT260395 WP_263592383.1 NZ_CP107008:c1941425-1941108 [Halomonas sp. M4R1S46]
MKPTPMTPEEREAALLDQLRRLMRGELSEGQVLRHLRREVLGMSQGAYADLVGVSRRTLSDLERDAGNASMASMNRVFRP
LGLRVGLVPRQPALLARLAEDADGP

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References