Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 374704..375314 Replicon chromosome
Accession NZ_CP107007
Organism Halomonas sp. GD1P12

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OCT39_RS01820 Protein ID WP_263586003.1
Coordinates 374704..374886 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OCT39_RS01825 Protein ID WP_263586004.1
Coordinates 374910..375314 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCT39_RS01800 (OCT39_01800) 369857..370015 - 159 WP_263585999.1 DUF1127 domain-containing protein -
OCT39_RS01805 (OCT39_01805) 370172..371602 + 1431 WP_263586000.1 PLP-dependent aminotransferase family protein -
OCT39_RS01810 (OCT39_01810) 371770..372540 + 771 WP_263586001.1 hypothetical protein -
OCT39_RS01815 (OCT39_01815) 372788..373093 - 306 WP_263586002.1 hypothetical protein -
OCT39_RS01820 (OCT39_01820) 374704..374886 + 183 WP_263586003.1 type II toxin-antitoxin system HicA family toxin Toxin
OCT39_RS01825 (OCT39_01825) 374910..375314 + 405 WP_263586004.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OCT39_RS01830 (OCT39_01830) 375555..378230 + 2676 WP_263586005.1 CRISPR-associated helicase Cas3' -
OCT39_RS01835 (OCT39_01835) 378314..380035 + 1722 WP_263586006.1 type I-E CRISPR-associated protein Cse1/CasA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6724.84 Da        Isoelectric Point: 10.7304

>T260392 WP_263586003.1 NZ_CP107007:374704-374886 [Halomonas sp. GD1P12]
VKSRELIKEMEADGWYLDRVSGSHHVFKHSTKPGSVPVPHPKKDLPKGTIHSIRKLAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14776.69 Da        Isoelectric Point: 4.9268

>AT260392 WP_263586004.1 NZ_CP107007:374910-375314 [Halomonas sp. GD1P12]
MQYPIAIEWGDENTATGIVIPDIPGAVTAGDTTEHAYEMAVEVAHIQLEELANDNKDIPMPRSIAEHRRNPQFEGYGWGI
IDIDITPYLGKTEKVNVTLPGHVIRQIDKYVTTHGIKSRSAFIASAALEKLTHA

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References