Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4032571..4033385 Replicon chromosome
Accession NZ_CP107005
Organism Escherichia coli strain SY22A1

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag OFB12_RS19835 Protein ID WP_001054376.1
Coordinates 4032571..4032828 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag OFB12_RS19840 Protein ID WP_001309181.1
Coordinates 4032840..4033385 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OFB12_RS19810 (4027859) 4027859..4028965 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
OFB12_RS19815 (4029030) 4029030..4030010 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
OFB12_RS19820 (4030120) 4030120..4030325 + 206 Protein_3873 HNH endonuclease -
OFB12_RS19825 (4030593) 4030593..4031833 - 1241 Protein_3874 helicase YjhR -
OFB12_RS19830 (4031949) 4031949..4032080 + 132 WP_001309182.1 hypothetical protein -
OFB12_RS19835 (4032571) 4032571..4032828 + 258 WP_001054376.1 YjhX family toxin Toxin
OFB12_RS19840 (4032840) 4032840..4033385 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
OFB12_RS19845 (4033441) 4033441..4034187 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
OFB12_RS19850 (4034356) 4034356..4034574 + 219 Protein_3879 hypothetical protein -
OFB12_RS19855 (4034612) 4034612..4034728 + 117 Protein_3880 VOC family protein -
OFB12_RS19860 (4034973) 4034973..4036094 + 1122 WP_000010829.1 M42 family metallopeptidase -
OFB12_RS19865 (4036091) 4036091..4036369 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
OFB12_RS19870 (4036381) 4036381..4037694 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4017768..4041609 23841


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T260389 WP_001054376.1 NZ_CP107005:4032571-4032828 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT260389 WP_001309181.1 NZ_CP107005:4032840-4033385 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References