Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3561055..3561673 Replicon chromosome
Accession NZ_CP107002
Organism Escherichia coli strain SY22C3

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag OFB02_RS17455 Protein ID WP_001290581.1
Coordinates 3561455..3561673 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag OFB02_RS17450 Protein ID WP_000344800.1
Coordinates 3561055..3561429 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OFB02_RS17440 (3556144) 3556144..3557337 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OFB02_RS17445 (3557360) 3557360..3560509 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
OFB02_RS17450 (3561055) 3561055..3561429 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
OFB02_RS17455 (3561455) 3561455..3561673 + 219 WP_001290581.1 HHA domain-containing protein Toxin
OFB02_RS17460 (3561845) 3561845..3562396 + 552 WP_000102564.1 maltose O-acetyltransferase -
OFB02_RS17465 (3562512) 3562512..3562982 + 471 WP_000136192.1 YlaC family protein -
OFB02_RS17470 (3563146) 3563146..3564696 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
OFB02_RS17475 (3564738) 3564738..3565091 - 354 WP_000878140.1 DUF1428 domain-containing protein -
OFB02_RS17485 (3565470) 3565470..3565781 + 312 WP_000409911.1 MGMT family protein -
OFB02_RS17490 (3565812) 3565812..3566384 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8678.06 Da        Isoelectric Point: 8.9008

>T260316 WP_001290581.1 NZ_CP107002:3561455-3561673 [Escherichia coli]
MSEKFLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT260316 WP_000344800.1 NZ_CP107002:3561055-3561429 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References