Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4426865..4427522 Replicon chromosome
Accession NC_016845
Organism Klebsiella pneumoniae subsp. pneumoniae HS11286

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3GSW7
Locus tag KPHS_43920 Protein ID YP_005228692.1
Coordinates 4426865..4427275 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3GY41
Locus tag KPHS_43930 Protein ID YP_005228693.1
Coordinates 4427256..4427522 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPHS_43880 4422865..4424598 - 1734 YP_005228688.1 ssDNA exonuclease RecJ -
KPHS_43890 4424604..4425317 - 714 YP_005228689.1 thiol:disulfide interchange protein DsbC -
KPHS_43900 4425340..4426236 - 897 YP_005228690.1 site-specific tyrosine recombinase XerD -
KPHS_43910 4426337..4426858 + 522 YP_005228691.1 flavodoxin -
KPHS_43920 4426865..4427275 - 411 YP_005228692.1 protein YgfX Toxin
KPHS_43930 4427256..4427522 - 267 YP_005228693.1 FAD assembly factor SdhE Antitoxin
KPHS_43940 4427768..4428751 + 984 YP_005228694.1 tRNA-modifying protein YgfZ -
KPHS_43950 4428902..4429561 - 660 YP_005228695.1 putative oxidoreductase -
KPHS_43960 4429725..4430036 - 312 YP_005228696.1 ASCH domain-containing protein -
KPHS_43970 4430086..4430814 + 729 YP_005228697.1 putative regulator -
KPHS_43980 4430933..4432366 + 1434 YP_005228698.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T26029 YP_005228692.1 NC_016845:c4427275-4426865 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T26029 NC_016845:c4427275-4426865 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT26029 YP_005228693.1 NC_016845:c4427522-4427256 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT26029 NC_016845:c4427522-4427256 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References