260285

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1812005..1812836 Replicon chromosome
Accession NZ_CP107001
Organism Escherichia coli strain SY22B5

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag OFB11_RS08710 Protein ID WP_000854814.1
Coordinates 1812005..1812379 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag OFB11_RS08715 Protein ID WP_001285584.1
Coordinates 1812468..1812836 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OFB11_RS08670 (1807401) 1807401..1808567 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
OFB11_RS08675 (1808686) 1808686..1809159 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
OFB11_RS08680 (1809357) 1809357..1810415 + 1059 WP_001200891.1 FUSC family protein -
OFB11_RS08685 (1810587) 1810587..1810916 + 330 WP_000450409.1 DUF496 family protein -
OFB11_RS08690 (1811017) 1811017..1811151 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
OFB11_RS08695 (1811271) 1811271..1811399 + 129 Protein_1699 transposase domain-containing protein -
OFB11_RS08700 (1811688) 1811688..1811768 - 81 Protein_1700 hypothetical protein -
OFB11_RS08705 (1811814) 1811814..1812008 - 195 WP_000988600.1 DUF5983 family protein -
OFB11_RS08710 (1812005) 1812005..1812379 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
OFB11_RS08715 (1812468) 1812468..1812836 - 369 WP_001285584.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
OFB11_RS08720 (1812910) 1812910..1813131 - 222 WP_000692323.1 DUF987 domain-containing protein -
OFB11_RS08725 (1813194) 1813194..1813640 - 447 WP_000187523.1 RadC family protein -
OFB11_RS08730 (1813637) 1813637..1815169 - 1533 WP_001350525.1 protein YeeR -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T260285 WP_000854814.1 NZ_CP107001:c1812379-1812005 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp


Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT260285 WP_001285584.1 NZ_CP107001:c1812836-1812468 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829FY50


Antitoxin

Source ID Structure
AlphaFold DB A0A1M2E8G6

References