Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4119028..4119623 Replicon chromosome
Accession NZ_CP107000
Organism Escherichia coli strain SY22B2

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag OFB04_RS20280 Protein ID WP_000239577.1
Coordinates 4119028..4119378 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag OFB04_RS20285 Protein ID WP_001223208.1
Coordinates 4119372..4119623 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OFB04_RS20260 (4115365) 4115365..4115496 - 132 Protein_3960 ABC transporter permease -
OFB04_RS20265 (4115510) 4115510..4117012 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
OFB04_RS20270 (4117152) 4117152..4118108 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
OFB04_RS20275 (4118418) 4118418..4118948 + 531 WP_000055075.1 inorganic diphosphatase -
OFB04_RS20280 (4119028) 4119028..4119378 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
OFB04_RS20285 (4119372) 4119372..4119623 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
OFB04_RS20290 (4119835) 4119835..4120176 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
OFB04_RS20295 (4120179) 4120179..4123958 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T260275 WP_000239577.1 NZ_CP107000:c4119378-4119028 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT260275 WP_001223208.1 NZ_CP107000:c4119623-4119372 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References