Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4214989..4215486 Replicon chromosome
Accession NZ_CP106998
Organism Escherichia coli strain SY221

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag OFB08_RS20775 Protein ID WP_001173343.1
Coordinates 4214989..4215162 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag OFB08_RS20780 Protein ID WP_000398619.1
Coordinates 4215190..4215486 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OFB08_RS20765 (4211659) 4211659..4213116 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
OFB08_RS20770 (4213353) 4213353..4214870 + 1518 WP_001295074.1 lysine--tRNA ligase -
OFB08_RS20775 (4214989) 4214989..4215162 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
OFB08_RS20780 (4215190) 4215190..4215486 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
OFB08_RS20785 (4215713) 4215713..4215985 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
OFB08_RS20790 (4215997) 4215997..4216227 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
OFB08_RS20795 (4216408) 4216408..4218039 + 1632 WP_001216477.1 sensor histidine kinase -
OFB08_RS20800 (4218036) 4218036..4218755 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T260230 WP_001173343.1 NZ_CP106998:c4215162-4214989 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT260230 WP_000398619.1 NZ_CP106998:c4215486-4215190 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References