26019

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1240086..1240705 Replicon chromosome
Accession NC_016845
Organism Klebsiella pneumoniae subsp. pneumoniae HS11286

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3GSW0
Locus tag KPHS_11860 Protein ID YP_005225486.1
Coordinates 1240086..1240304 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3GJ93
Locus tag KPHS_11870 Protein ID YP_005225487.1
Coordinates 1240331..1240705 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPHS_11790 1236134..1236397 + 264 YP_005225479.1 putative 50S ribosomal protein L31 (second copy) -
KPHS_11800 1236397..1236579 + 183 YP_005225480.1 50S ribosomal protein L36 -
KPHS_11810 1236533..1237231 - 699 YP_005225481.1 acetyltransferase -
KPHS_11820 1237332..1238783 + 1452 YP_005225482.1 transcriptional regulator -
KPHS_11830 1238758..1239228 - 471 YP_005225483.1 YlaC family protein -
KPHS_11840 1239249..1239389 + 141 YP_005225484.1 hypothetical protein -
KPHS_11850 1239361..1239927 - 567 YP_005225485.1 maltose O-acetyltransferase -
KPHS_11860 1240086..1240304 - 219 YP_005225486.1 hemolysin expression-modulating protein Toxin
KPHS_11870 1240331..1240705 - 375 YP_005225487.1 Hha toxicity modulator TomB Antitoxin
KPHS_11880 1241191..1244337 - 3147 YP_005225488.1 acridine efflux pump -
KPHS_11890 1244360..1245553 - 1194 YP_005225489.1 acridine efflux pump -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T26019 YP_005225486.1 NC_016845:c1240304-1240086 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T26019 NC_016845:c1240304-1240086 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT26019 YP_005225487.1 NC_016845:c1240705-1240331 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT26019 NC_016845:c1240705-1240331 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References