Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 523291..523807 Replicon chromosome
Accession NC_016845
Organism Klebsiella pneumoniae subsp. pneumoniae HS11286

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3GMH2
Locus tag KPHS_04890 Protein ID YP_005224789.1
Coordinates 523523..523807 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0H3GLP0
Locus tag KPHS_04880 Protein ID YP_005224788.1
Coordinates 523291..523533 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPHS_04850 519319..520059 + 741 YP_005224785.1 KDGP aldolase family protein -
KPHS_04860 520126..521280 + 1155 YP_005224786.1 putative isomerase -
KPHS_04870 521303..523213 + 1911 YP_005224787.1 putative mannitol/fructose-specific PTS family enzyme IIA component -
KPHS_04880 523291..523533 + 243 YP_005224788.1 bifunctional antitoxin/transcriptional repressor RelB Antitoxin
KPHS_04890 523523..523807 + 285 YP_005224789.1 putative inner membrane protein Toxin
KPHS_04900 523811..524275 - 465 YP_005224790.1 anaerobic ribonucleotide reductase-activating protein -
KPHS_04910 524516..526654 - 2139 YP_005224791.1 anaerobic ribonucleoside triphosphate reductase -
KPHS_04920 526924..527052 + 129 YP_005224792.1 hypothetical protein -
KPHS_04930 527011..527754 - 744 YP_005224793.1 MurR/RpiR family transcriptional regulator -
KPHS_04940 527757..527930 - 174 YP_005224794.1 hypothetical protein -
KPHS_04950 528060..528323 + 264 YP_005224795.1 putative phosphotransferase protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T26017 YP_005224789.1 NC_016845:523523-523807 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T26017 NC_016845:523523-523807 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT26017 YP_005224788.1 NC_016845:523291-523533 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT26017 NC_016845:523291-523533 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References