Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 523291..523807 | Replicon | chromosome |
Accession | NC_016845 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae HS11286 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0H3GMH2 |
Locus tag | KPHS_04890 | Protein ID | YP_005224789.1 |
Coordinates | 523523..523807 (+) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A0H3GLP0 |
Locus tag | KPHS_04880 | Protein ID | YP_005224788.1 |
Coordinates | 523291..523533 (+) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KPHS_04850 | 519319..520059 | + | 741 | YP_005224785.1 | KDGP aldolase family protein | - |
KPHS_04860 | 520126..521280 | + | 1155 | YP_005224786.1 | putative isomerase | - |
KPHS_04870 | 521303..523213 | + | 1911 | YP_005224787.1 | putative mannitol/fructose-specific PTS family enzyme IIA component | - |
KPHS_04880 | 523291..523533 | + | 243 | YP_005224788.1 | bifunctional antitoxin/transcriptional repressor RelB | Antitoxin |
KPHS_04890 | 523523..523807 | + | 285 | YP_005224789.1 | putative inner membrane protein | Toxin |
KPHS_04900 | 523811..524275 | - | 465 | YP_005224790.1 | anaerobic ribonucleotide reductase-activating protein | - |
KPHS_04910 | 524516..526654 | - | 2139 | YP_005224791.1 | anaerobic ribonucleoside triphosphate reductase | - |
KPHS_04920 | 526924..527052 | + | 129 | YP_005224792.1 | hypothetical protein | - |
KPHS_04930 | 527011..527754 | - | 744 | YP_005224793.1 | MurR/RpiR family transcriptional regulator | - |
KPHS_04940 | 527757..527930 | - | 174 | YP_005224794.1 | hypothetical protein | - |
KPHS_04950 | 528060..528323 | + | 264 | YP_005224795.1 | putative phosphotransferase protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11125.95 Da Isoelectric Point: 10.3787
>T26017 YP_005224789.1 NC_016845:523523-523807 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
Download Length: 285 bp
>T26017 NC_016845:523523-523807 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9045.55 Da Isoelectric Point: 6.3340
>AT26017 YP_005224788.1 NC_016845:523291-523533 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
Download Length: 243 bp
>AT26017 NC_016845:523291-523533 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GMH2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GLP0 |