26015

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 42952..43577 Replicon chromosome
Accession NC_016845
Organism Klebsiella pneumoniae subsp. pneumoniae HS11286

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H3GPK8
Locus tag KPHS_00360 Protein ID YP_005224336.1
Coordinates 43194..43577 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0H3GGU9
Locus tag KPHS_00350 Protein ID YP_005224335.1
Coordinates 42952..43194 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPHS_00300 38943..39542 + 600 YP_005224330.1 phosphatase -
KPHS_00310 39536..40396 + 861 YP_005224331.1 ribonuclease BN -
KPHS_00320 40393..40830 + 438 YP_005224332.1 D-tyrosyl-tRNA deacylase -
KPHS_00330 40815..41816 + 1002 YP_005224333.1 putative acetyltransferase -
KPHS_00340 41830..42747 - 918 YP_005224334.1 acetyl esterase -
KPHS_00350 42952..43194 + 243 YP_005224335.1 ribbon-helix-helix domain-containing protein Antitoxin
KPHS_00360 43194..43577 + 384 YP_005224336.1 putative 2-component transcriptional regulator Toxin
KPHS_00370 43751..44680 - 930 YP_005224337.1 formate dehydrogenase accessory protein FdhE -
KPHS_00380 44677..45312 - 636 YP_005224338.1 formate dehydrogenase-O subunit gamma -
KPHS_00390 45309..46211 - 903 YP_005224339.1 formate dehydrogenase-O, Fe-S subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T26015 YP_005224336.1 NC_016845:43194-43577 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T26015 NC_016845:43194-43577 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT26015 YP_005224335.1 NC_016845:42952-43194 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT26015 NC_016845:42952-43194 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References