260115

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 5371207..5371842 Replicon chromosome
Accession NZ_CP106992
Organism Paenibacillus thiaminolyticus strain SY20

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NDS46_RS24425 Protein ID WP_087444735.1
Coordinates 5371207..5371557 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2W4HCL7
Locus tag NDS46_RS24430 Protein ID WP_040731899.1
Coordinates 5371561..5371842 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDS46_RS24420 (NDS46_24450) 5368219..5370690 + 2472 WP_272046762.1 M60 family metallopeptidase -
NDS46_RS24425 (NDS46_24455) 5371207..5371557 - 351 WP_087444735.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NDS46_RS24430 (NDS46_24460) 5371561..5371842 - 282 WP_040731899.1 CopG family ribbon-helix-helix protein Antitoxin
NDS46_RS24435 (NDS46_24465) 5372093..5373286 - 1194 WP_272046763.1 alanine racemase -
NDS46_RS24440 (NDS46_24470) 5373528..5374646 - 1119 WP_272046764.1 DUF4367 domain-containing protein -
NDS46_RS24445 (NDS46_24475) 5374963..5375214 - 252 WP_272046765.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12862.87 Da        Isoelectric Point: 5.6312

>T260115 WP_087444735.1 NZ_CP106992:c5371557-5371207 [Paenibacillus thiaminolyticus]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMRKVDDGLLISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10735.45 Da        Isoelectric Point: 8.4934

>AT260115 WP_040731899.1 NZ_CP106992:c5371842-5371561 [Paenibacillus thiaminolyticus]
VANIQNTKRIMISLPDQLLQEVDGIVAMEKSNRSEFIRQAMKLYLQERKKRHIRESMQRGYMEMAKINLTMASEAFYAEV
EADGTLDRLVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2W4HCL7

References