260114

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 3034..3622 Replicon plasmid pNY13623-2
Accession NZ_CP106990
Organism Acinetobacter baumannii strain NY13623

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag OC371_RS19895 Protein ID WP_000438826.1
Coordinates 3034..3321 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag OC371_RS19900 Protein ID WP_001983304.1
Coordinates 3308..3622 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OC371_RS19875 (OC371_19875) 273..1223 + 951 WP_001208778.1 replication initiation protein RepM -
OC371_RS19880 (OC371_19880) 1216..1791 + 576 WP_001096619.1 plasmid replication DNA-binding protein -
OC371_RS19885 (OC371_19885) 1811..1954 + 144 WP_001125246.1 hypothetical protein -
OC371_RS19890 (OC371_19890) 2143..2661 - 519 WP_000447193.1 tetratricopeptide repeat protein -
OC371_RS19895 (OC371_19895) 3034..3321 + 288 WP_000438826.1 BrnT family toxin Toxin
OC371_RS19900 (OC371_19900) 3308..3622 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
OC371_RS19905 (OC371_19905) 3750..6161 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
OC371_RS19910 (OC371_19910) 6466..6927 + 462 WP_000761346.1 DIP1984 family protein -
OC371_RS19915 (OC371_19915) 7363..8331 - 969 WP_012308653.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10967 10967
- flank IS/Tn - - 7363..8388 1025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T260114 WP_000438826.1 NZ_CP106990:3034-3321 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT260114 WP_001983304.1 NZ_CP106990:3308-3622 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References