Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 3195836..3196814 Replicon chromosome
Accession NZ_CP106987
Organism Bacillus cereus strain IBA1

Toxin (Protein)


Gene name spoIISA Uniprot ID W8Y388
Locus tag OF864_RS16350 Protein ID WP_000624977.1
Coordinates 3195836..3196573 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W8YZL5
Locus tag OF864_RS16355 Protein ID WP_000237818.1
Coordinates 3196686..3196814 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF864_RS16325 (OF864_16330) 3191452..3191859 + 408 WP_000063589.1 VOC family protein -
OF864_RS16330 (OF864_16335) 3191872..3192261 + 390 Protein_3141 SAM-dependent methyltransferase -
OF864_RS16335 (OF864_16340) 3192419..3194104 - 1686 WP_033689678.1 alpha-keto acid decarboxylase family protein -
OF864_RS16340 (OF864_16345) 3194212..3194694 + 483 WP_000191888.1 MarR family winged helix-turn-helix transcriptional regulator -
OF864_RS16345 (OF864_16350) 3194861..3195598 + 738 WP_000594150.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
OF864_RS16350 (OF864_16355) 3195836..3196573 + 738 WP_000624977.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
OF864_RS16355 (OF864_16360) 3196686..3196814 + 129 WP_000237818.1 hypothetical protein Antitoxin
OF864_RS16360 (OF864_16365) 3196887..3197063 + 177 WP_000852629.1 stage II sporulation protein SB -
OF864_RS16365 (OF864_16370) 3197082..3197471 - 390 WP_000713866.1 YxeA family protein -
OF864_RS16370 (OF864_16375) 3197683..3199152 + 1470 WP_283502302.1 beta-Ala-His dipeptidase -
OF864_RS16375 (OF864_16380) 3199398..3200207 + 810 WP_044584465.1 papain-like cysteine protease family protein -
OF864_RS16380 (OF864_16385) 3200233..3200835 + 603 WP_000517260.1 hypothetical protein -
OF864_RS16385 (OF864_16390) 3201076..3201327 - 252 WP_030025648.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28307.03 Da        Isoelectric Point: 8.2998

>T260110 WP_000624977.1 NZ_CP106987:3195836-3196573 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 5011.40 Da        Isoelectric Point: 3.9150

>AT260110 WP_000237818.1 NZ_CP106987:3196686-3196814 [Bacillus cereus]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W8Y388

Antitoxin

Source ID Structure
AlphaFold DB W8YZL5

References