Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 1092723..1093365 Replicon chromosome
Accession NZ_CP106987
Organism Bacillus cereus strain IBA1

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag OF864_RS05445 Protein ID WP_000635965.1
Coordinates 1093015..1093365 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag OF864_RS05440 Protein ID WP_000004570.1
Coordinates 1092723..1093010 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF864_RS05415 (OF864_05420) 1088040..1089002 + 963 WP_000961161.1 UV DNA damage repair endonuclease UvsE -
OF864_RS05420 (OF864_05425) 1088995..1089567 - 573 WP_000908523.1 rhomboid family intramembrane serine protease -
OF864_RS05425 (OF864_05430) 1089661..1090020 + 360 WP_000583417.1 holo-ACP synthase -
OF864_RS05430 (OF864_05435) 1090177..1091127 + 951 WP_002004297.1 outer membrane lipoprotein carrier protein LolA -
OF864_RS05435 (OF864_05440) 1091245..1092414 + 1170 WP_000390617.1 alanine racemase -
OF864_RS05440 (OF864_05445) 1092723..1093010 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
OF864_RS05445 (OF864_05450) 1093015..1093365 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
OF864_RS05450 (OF864_05455) 1093433..1095601 + 2169 WP_000426241.1 Tex family protein -
OF864_RS05455 (OF864_05460) 1095659..1095775 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
OF864_RS05460 (OF864_05465) 1095970..1096428 + 459 WP_000344241.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T260109 WP_000635965.1 NZ_CP106987:1093015-1093365 [Bacillus cereus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT260109 WP_000004570.1 NZ_CP106987:1092723-1093010 [Bacillus cereus]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References