Detailed information of TA system TA260105

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5114831..5116512
• Replicon: chromosome
• Accession: NZ_CP106964
• Organism: Klebsiella variicola strain SY1

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: OCU08_RS24750
• Protein ID: WP_263526339.1
• Coordinates: 5114831..5115748 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A0B7GCX3
• Locus tag: OCU08_RS24755
• Protein ID: WP_008807257.1
• Coordinates: 5115754..5116512 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU08_RS24730	5110137..5111657	+	1521	WP_072046021.1	sugar ABC transporter ATP-binding protein	-
OCU08_RS24735	5111654..5112652	+	999	WP_004206363.1	ribose ABC transporter permease	-
OCU08_RS24740	5112683..5113624	+	942	WP_012543155.1	ABC transporter substrate-binding protein	-
OCU08_RS24745	5113699..5114706	+	1008	WP_023339423.1	carbohydrate kinase family protein	-
OCU08_RS24750	5114831..5115748	-	918	WP_263526339.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
OCU08_RS24755	5115754..5116512	-	759	WP_008807257.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
OCU08_RS24760	5116597..5117325	-	729	WP_008807258.1	response regulator transcription factor	-
OCU08_RS24765	5117598..5119745	+	2148	WP_077598880.1	formate dehydrogenase subunit alpha	-
OCU08_RS24770	5120099..5120785	+	687	WP_016160120.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34731.10 Da
• Isoelectric Point: 5.2585

>T260105 WP_263526339.1 NZ_CP106964:c5115748-5114831 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVERGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CVTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28653.01 Da
• Isoelectric Point: 10.1988

>AT260105 WP_008807257.1 NZ_CP106964:c5116512-5115754 [Klebsiella variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A0A0B7GCX3