Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4950738..4951254 Replicon chromosome
Accession NZ_CP106964
Organism Klebsiella variicola strain SY1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag OCU08_RS23935 Protein ID WP_022065401.1
Coordinates 4950738..4951022 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OCU08_RS23940 Protein ID WP_002886901.1
Coordinates 4951012..4951254 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU08_RS23920 4945841..4947496 + 1656 WP_117146636.1 alpha,alpha-phosphotrehalase -
OCU08_RS23925 4947882..4950020 + 2139 WP_044614392.1 anaerobic ribonucleoside-triphosphate reductase -
OCU08_RS23930 4950270..4950734 + 465 WP_012969085.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OCU08_RS23935 4950738..4951022 - 285 WP_022065401.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCU08_RS23940 4951012..4951254 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OCU08_RS23945 4951332..4953242 - 1911 WP_012969086.1 PRD domain-containing protein -
OCU08_RS23950 4953265..4954419 - 1155 WP_012969087.1 lactonase family protein -
OCU08_RS23955 4954545..4955285 - 741 WP_008807137.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11128.97 Da        Isoelectric Point: 10.2849

>T260104 WP_022065401.1 NZ_CP106964:c4951022-4950738 [Klebsiella variicola]
MTYELEFDPRAWREWQMPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT260104 WP_002886901.1 NZ_CP106964:c4951254-4951012 [Klebsiella variicola]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References