Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2742117..2743705 Replicon chromosome
Accession NZ_CP106964
Organism Klebsiella variicola strain SY1

Toxin (Protein)


Gene name hipA Uniprot ID A0A1F2MCM0
Locus tag OCU08_RS13320 Protein ID WP_008804919.1
Coordinates 2742117..2743439 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MCN9
Locus tag OCU08_RS13325 Protein ID WP_008804920.1
Coordinates 2743439..2743705 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU08_RS13305 2737182..2739683 + 2502 WP_101880711.1 fimbria/pilus outer membrane usher protein -
OCU08_RS13310 2739671..2740675 + 1005 WP_101880712.1 fimbrial protein -
OCU08_RS13315 2740808..2742100 + 1293 WP_012968243.1 glycoside hydrolase family 10 protein -
OCU08_RS13320 2742117..2743439 - 1323 WP_008804919.1 type II toxin-antitoxin system HipA family toxin Toxin
OCU08_RS13325 2743439..2743705 - 267 WP_008804920.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OCU08_RS13330 2743971..2744297 - 327 WP_008804921.1 hydroxyisourate hydrolase -
OCU08_RS13335 2744294..2744794 - 501 WP_049153027.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OCU08_RS13340 2744772..2746151 - 1380 WP_012968246.1 nucleobase:cation symporter-2 family protein -
OCU08_RS13345 2746496..2747650 + 1155 WP_101880713.1 FAD-dependent urate hydroxylase HpxO -
OCU08_RS13350 2747631..2748554 - 924 WP_023297602.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48911.26 Da        Isoelectric Point: 7.9109

>T260100 WP_008804919.1 NZ_CP106964:c2743439-2742117 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.30 Da        Isoelectric Point: 8.5912

>AT260100 WP_008804920.1 NZ_CP106964:c2743705-2743439 [Klebsiella variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2MCM0

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MCN9

References