Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1833091..1833681 Replicon chromosome
Accession NZ_CP106964
Organism Klebsiella variicola strain SY1

Toxin (Protein)


Gene name pemK Uniprot ID A0A1F2LYA2
Locus tag OCU08_RS08855 Protein ID WP_008804165.1
Coordinates 1833349..1833681 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A1F2LZQ3
Locus tag OCU08_RS08850 Protein ID WP_012541132.1
Coordinates 1833091..1833348 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU08_RS08830 1828698..1829273 + 576 WP_072122291.1 hypothetical protein -
OCU08_RS08835 1829452..1830288 + 837 WP_008804155.1 alpha/beta hydrolase -
OCU08_RS08840 1830495..1831466 + 972 WP_012541130.1 sensor domain-containing diguanylate cyclase -
OCU08_RS08845 1831463..1832563 - 1101 WP_072122293.1 AarF/UbiB family protein -
OCU08_RS08850 1833091..1833348 + 258 WP_012541132.1 antitoxin Antitoxin
OCU08_RS08855 1833349..1833681 + 333 WP_008804165.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OCU08_RS08865 1834004..1835440 + 1437 WP_016161429.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
OCU08_RS08875 1835815..1837269 - 1455 WP_008804170.1 AMP nucleosidase -
OCU08_RS08880 1837400..1837645 - 246 WP_008804171.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11867.71 Da        Isoelectric Point: 10.1839

>T260095 WP_008804165.1 NZ_CP106964:1833349-1833681 [Klebsiella variicola]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDAVVNEVLARLDAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9420.91 Da        Isoelectric Point: 4.4915

>AT260095 WP_012541132.1 NZ_CP106964:1833091-1833348 [Klebsiella variicola]
MYKTRLKKVGGSIMLAVPPAVLKALELSTDSEVGMTIDNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2LYA2

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZQ3

References