Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1637403..1638400 Replicon chromosome
Accession NZ_CP106964
Organism Klebsiella variicola strain SY1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OCU08_RS08025 Protein ID WP_228961040.1
Coordinates 1637846..1638400 (-) Length 185 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MDT5
Locus tag OCU08_RS08020 Protein ID WP_012541033.1
Coordinates 1637403..1637849 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU08_RS08005 1633698..1634696 + 999 WP_008804028.1 galactose/glucose ABC transporter substrate-binding protein MglB -
OCU08_RS08010 1634815..1636335 + 1521 WP_008804029.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
OCU08_RS08015 1636351..1637361 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
OCU08_RS08020 1637403..1637849 - 447 WP_012541033.1 helix-turn-helix transcriptional regulator Antitoxin
OCU08_RS08025 1637846..1638400 - 555 WP_228961040.1 HipA domain-containing protein Toxin
OCU08_RS08030 1638429..1638950 - 522 WP_257965174.1 phosphatidylinositol kinase -
OCU08_RS08035 1639065..1639796 - 732 WP_008804033.1 outer membrane permeability protein SanA -
OCU08_RS08040 1640073..1640957 - 885 WP_101880685.1 cytidine deaminase -
OCU08_RS08045 1641086..1641781 - 696 WP_008804035.1 CidB/LrgB family autolysis modulator -
OCU08_RS08050 1641771..1642175 - 405 WP_004201620.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(2-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20639.90 Da        Isoelectric Point: 5.7891

>T260094 WP_228961040.1 NZ_CP106964:c1638400-1637846 [Klebsiella variicola]
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEITLAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWIAPDTLLNALSETASQLVDLPSRLKARGVP
VQILEMPSIGFKFIPDKLARWGLL

Download         Length: 555 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16396.05 Da        Isoelectric Point: 10.5417

>AT260094 WP_012541033.1 NZ_CP106964:c1637849-1637403 [Klebsiella variicola]
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MDT5

References