Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 767373..768030 Replicon chromosome
Accession NZ_CP106964
Organism Klebsiella variicola strain SY1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OCU08_RS03795 Protein ID WP_002916310.1
Coordinates 767620..768030 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OCU08_RS03790 Protein ID WP_002916312.1
Coordinates 767373..767639 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU08_RS03765 762574..764007 - 1434 WP_072122037.1 6-phospho-beta-glucosidase BglA -
OCU08_RS03770 764127..764855 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
OCU08_RS03775 764906..765217 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
OCU08_RS03780 765381..766040 + 660 WP_008806429.1 hemolysin III family protein -
OCU08_RS03785 766144..767127 - 984 WP_012967246.1 tRNA-modifying protein YgfZ -
OCU08_RS03790 767373..767639 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OCU08_RS03795 767620..768030 + 411 WP_002916310.1 protein YgfX Toxin
OCU08_RS03800 768037..768558 - 522 WP_008806427.1 flavodoxin FldB -
OCU08_RS03805 768659..769555 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
OCU08_RS03810 769578..770291 + 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OCU08_RS03815 770297..772030 + 1734 WP_008806424.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T260093 WP_002916310.1 NZ_CP106964:767620-768030 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT260093 WP_002916312.1 NZ_CP106964:767373-767639 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References