Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 284214..284845 Replicon chromosome
Accession NZ_CP106964
Organism Klebsiella variicola strain SY1

Toxin (Protein)


Gene name hicA Uniprot ID A0A2V3KJT3
Locus tag OCU08_RS01285 Protein ID WP_044650325.1
Coordinates 284214..284489 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID R4YIG2
Locus tag OCU08_RS01290 Protein ID WP_004181489.1
Coordinates 284486..284845 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU08_RS01265 279450..279785 + 336 WP_002921203.1 universal stress protein UspB -
OCU08_RS01270 279845..281341 - 1497 WP_008806938.1 inorganic phosphate transporter PitA -
OCU08_RS01275 281571..282764 + 1194 WP_012967106.1 NAD(P)/FAD-dependent oxidoreductase -
OCU08_RS01280 282804..283817 - 1014 WP_012540371.1 magnesium transporter -
OCU08_RS01285 284214..284489 + 276 WP_044650325.1 type II toxin-antitoxin system HicA family toxin Toxin
OCU08_RS01290 284486..284845 + 360 WP_004181489.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OCU08_RS01295 284873..285274 - 402 WP_004181488.1 nickel-responsive transcriptional regulator NikR -
OCU08_RS01300 285262..286053 - 792 WP_012540373.1 nickel import ATP-binding protein NikE -
OCU08_RS01305 286050..286814 - 765 WP_008806946.1 nickel import ATP-binding protein NikD -
OCU08_RS01310 286814..287647 - 834 WP_012967107.1 nickel ABC transporter permease subunit NikC -
OCU08_RS01315 287644..288588 - 945 WP_023323359.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10279.91 Da        Isoelectric Point: 10.3165

>T260090 WP_044650325.1 NZ_CP106964:284214-284489 [Klebsiella variicola]
MEQQVLSLRNKQRHTLEQLFKIPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13313.02 Da        Isoelectric Point: 4.4605

>AT260090 WP_004181489.1 NZ_CP106964:284486-284845 [Klebsiella variicola]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCHEAGIEPYAHPEKMKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3KJT3

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2M5Q1

References