Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4307976..4308594 Replicon chromosome
Accession NZ_CP106929
Organism Escherichia coli strain MFDS1001074

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag OEG89_RS21405 Protein ID WP_001291435.1
Coordinates 4307976..4308194 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag OEG89_RS21410 Protein ID WP_000344800.1
Coordinates 4308220..4308594 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG89_RS21370 (4303265) 4303265..4303837 + 573 WP_000779831.1 YbaY family lipoprotein -
OEG89_RS21375 (4303868) 4303868..4304179 - 312 WP_000409911.1 MGMT family protein -
OEG89_RS21385 (4304558) 4304558..4304911 + 354 WP_000878140.1 DUF1428 domain-containing protein -
OEG89_RS21390 (4304953) 4304953..4306503 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
OEG89_RS21395 (4306667) 4306667..4307137 - 471 WP_000136192.1 YlaC family protein -
OEG89_RS21400 (4307253) 4307253..4307804 - 552 WP_000102564.1 maltose O-acetyltransferase -
OEG89_RS21405 (4307976) 4307976..4308194 - 219 WP_001291435.1 HHA domain-containing protein Toxin
OEG89_RS21410 (4308220) 4308220..4308594 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
OEG89_RS21415 (4309140) 4309140..4312289 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
OEG89_RS21420 (4312312) 4312312..4313505 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T260086 WP_001291435.1 NZ_CP106929:c4308194-4307976 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT260086 WP_000344800.1 NZ_CP106929:c4308594-4308220 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References