Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2185092..2185746 Replicon chromosome
Accession NZ_CP106929
Organism Escherichia coli strain MFDS1001074

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag OEG89_RS11035 Protein ID WP_000244777.1
Coordinates 2185092..2185499 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag OEG89_RS11040 Protein ID WP_000354046.1
Coordinates 2185480..2185746 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG89_RS11015 (2181049) 2181049..2182782 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
OEG89_RS11020 (2182788) 2182788..2183498 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OEG89_RS11025 (2183523) 2183523..2184419 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
OEG89_RS11030 (2184531) 2184531..2185052 + 522 WP_001055874.1 flavodoxin FldB -
OEG89_RS11035 (2185092) 2185092..2185499 - 408 WP_000244777.1 protein YgfX Toxin
OEG89_RS11040 (2185480) 2185480..2185746 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
OEG89_RS11045 (2185989) 2185989..2186969 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
OEG89_RS11050 (2187165) 2187165..2187824 - 660 WP_000250274.1 hemolysin III family protein -
OEG89_RS11055 (2187988) 2187988..2188299 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
OEG89_RS11060 (2188344) 2188344..2189777 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
OEG89_RS11065 (2189834) 2189834..2190577 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T260077 WP_000244777.1 NZ_CP106929:c2185499-2185092 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT260077 WP_000354046.1 NZ_CP106929:c2185746-2185480 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References