Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 571427..572065 Replicon chromosome
Accession NZ_CP106929
Organism Escherichia coli strain MFDS1001074

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OEG89_RS02900 Protein ID WP_000813794.1
Coordinates 571427..571603 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OEG89_RS02905 Protein ID WP_001270286.1
Coordinates 571649..572065 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG89_RS02880 (567046) 567046..568221 - 1176 WP_001236265.1 BenE family transporter YdcO -
OEG89_RS02885 (568313) 568313..568849 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
OEG89_RS02890 (568922) 568922..570883 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OEG89_RS02895 (570975) 570975..571205 - 231 WP_000494244.1 YncJ family protein -
OEG89_RS02900 (571427) 571427..571603 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OEG89_RS02905 (571649) 571649..572065 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OEG89_RS02910 (572144) 572144..573550 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
OEG89_RS02915 (573795) 573795..574940 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
OEG89_RS02920 (574958) 574958..575971 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
OEG89_RS02925 (575972) 575972..576913 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T260067 WP_000813794.1 NZ_CP106929:571427-571603 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT260067 WP_001270286.1 NZ_CP106929:571649-572065 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References