Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4362965..4363462 Replicon chromosome
Accession NZ_CP106924
Organism Escherichia coli strain MFDS1016424

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag OEG87_RS21335 Protein ID WP_001173343.1
Coordinates 4362965..4363138 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag OEG87_RS21340 Protein ID WP_000398619.1
Coordinates 4363166..4363462 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG87_RS21325 (4359635) 4359635..4361092 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
OEG87_RS21330 (4361329) 4361329..4362846 + 1518 WP_001295074.1 lysine--tRNA ligase -
OEG87_RS21335 (4362965) 4362965..4363138 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
OEG87_RS21340 (4363166) 4363166..4363462 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
OEG87_RS21345 (4363689) 4363689..4363961 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
OEG87_RS21350 (4363973) 4363973..4364203 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
OEG87_RS21355 (4364384) 4364384..4366015 + 1632 WP_001216487.1 sensor histidine kinase -
OEG87_RS21360 (4366012) 4366012..4366731 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T260062 WP_001173343.1 NZ_CP106924:c4363138-4362965 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT260062 WP_000398619.1 NZ_CP106924:c4363462-4363166 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References