Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3557435..3558053 Replicon chromosome
Accession NZ_CP106924
Organism Escherichia coli strain MFDS1016424

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag OEG87_RS17515 Protein ID WP_001291435.1
Coordinates 3557835..3558053 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag OEG87_RS17510 Protein ID WP_000344800.1
Coordinates 3557435..3557809 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG87_RS17500 (3552524) 3552524..3553717 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OEG87_RS17505 (3553740) 3553740..3556889 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
OEG87_RS17510 (3557435) 3557435..3557809 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
OEG87_RS17515 (3557835) 3557835..3558053 + 219 WP_001291435.1 HHA domain-containing protein Toxin
OEG87_RS17520 (3558225) 3558225..3558776 + 552 WP_000102564.1 maltose O-acetyltransferase -
OEG87_RS17525 (3558892) 3558892..3559362 + 471 WP_000136192.1 YlaC family protein -
OEG87_RS17530 (3559526) 3559526..3561076 + 1551 WP_096838820.1 cyclic-guanylate-specific phosphodiesterase PdeB -
OEG87_RS17535 (3561118) 3561118..3561471 - 354 WP_000878140.1 DUF1428 domain-containing protein -
OEG87_RS17545 (3561850) 3561850..3562161 + 312 WP_000409911.1 MGMT family protein -
OEG87_RS17550 (3562192) 3562192..3562764 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T260057 WP_001291435.1 NZ_CP106924:3557835-3558053 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT260057 WP_000344800.1 NZ_CP106924:3557435-3557809 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References