Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2381915..2382553 Replicon chromosome
Accession NZ_CP106924
Organism Escherichia coli strain MFDS1016424

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OEG87_RS11570 Protein ID WP_000813794.1
Coordinates 2382377..2382553 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OEG87_RS11565 Protein ID WP_001270286.1
Coordinates 2381915..2382331 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG87_RS11545 (2377067) 2377067..2378008 - 942 WP_001251315.1 ABC transporter permease -
OEG87_RS11550 (2378009) 2378009..2379022 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
OEG87_RS11555 (2379040) 2379040..2380185 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
OEG87_RS11560 (2380430) 2380430..2381836 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
OEG87_RS11565 (2381915) 2381915..2382331 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OEG87_RS11570 (2382377) 2382377..2382553 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OEG87_RS11575 (2382775) 2382775..2383005 + 231 WP_000494244.1 YncJ family protein -
OEG87_RS11580 (2383097) 2383097..2385058 - 1962 WP_075826559.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OEG87_RS11585 (2385131) 2385131..2385667 - 537 WP_000429152.1 DNA-binding transcriptional regulator SutR -
OEG87_RS11590 (2385759) 2385759..2386934 + 1176 WP_001236296.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2386974..2388122 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T260056 WP_000813794.1 NZ_CP106924:c2382553-2382377 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT260056 WP_001270286.1 NZ_CP106924:c2382331-2381915 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References