Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2291689..2293277 Replicon chromosome
Accession NZ_CP106924
Organism Escherichia coli strain MFDS1016424

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OEG87_RS11195 Protein ID WP_001362359.1
Coordinates 2291955..2293277 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OEG87_RS11190 Protein ID WP_001296726.1
Coordinates 2291689..2291955 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG87_RS11180 (2286918) 2286918..2288510 + 1593 WP_000113127.1 autoinducer-2 kinase -
OEG87_RS11185 (2289041) 2289041..2291480 + 2440 Protein_2186 autotransporter outer membrane beta-barrel domain-containing protein -
OEG87_RS11190 (2291689) 2291689..2291955 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OEG87_RS11195 (2291955) 2291955..2293277 + 1323 WP_001362359.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
OEG87_RS11200 (2293584) 2293584..2293792 + 209 Protein_2189 AraC family transcriptional regulator -
OEG87_RS11205 (2294224) 2294224..2294787 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
OEG87_RS11210 (2295148) 2295148..2295858 + 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA 2291508..2307771 16263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49391.04 Da        Isoelectric Point: 9.1161

>T260055 WP_001362359.1 NZ_CP106924:2291955-2293277 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLRREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT260055 WP_001296726.1 NZ_CP106924:2291689-2291955 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References