Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1329616..1330241 Replicon chromosome
Accession NZ_CP106924
Organism Escherichia coli strain MFDS1016424

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OEG87_RS06535 Protein ID WP_000911330.1
Coordinates 1329843..1330241 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag OEG87_RS06530 Protein ID WP_000450524.1
Coordinates 1329616..1329843 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG87_RS06505 (1325419) 1325419..1325889 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
OEG87_RS06510 (1325889) 1325889..1326461 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
OEG87_RS06515 (1326607) 1326607..1327485 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
OEG87_RS06520 (1327502) 1327502..1328536 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
OEG87_RS06525 (1328749) 1328749..1329462 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
OEG87_RS06530 (1329616) 1329616..1329843 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
OEG87_RS06535 (1329843) 1329843..1330241 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
OEG87_RS06540 (1330388) 1330388..1331251 + 864 WP_001267495.1 neutral zinc metallopeptidase -
OEG87_RS06545 (1331266) 1331266..1333281 + 2016 WP_075826571.1 tRNA cytosine(34) acetyltransferase TmcA -
OEG87_RS06550 (1333355) 1333355..1334053 + 699 WP_000679812.1 esterase -
OEG87_RS06555 (1334163) 1334163..1334363 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T260048 WP_000911330.1 NZ_CP106924:1329843-1330241 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT260048 WP_000450524.1 NZ_CP106924:1329616-1329843 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References