260046

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1007442..1008025 Replicon chromosome
Accession NZ_CP106924
Organism Escherichia coli strain MFDS1016424

Toxin (Protein)


Gene name mazF Uniprot ID U9XFN8
Locus tag OEG87_RS04880 Protein ID WP_000254745.1
Coordinates 1007690..1008025 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag OEG87_RS04875 Protein ID WP_000581937.1
Coordinates 1007442..1007690 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG87_RS04865 (1003781) 1003781..1005082 + 1302 WP_000046800.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
OEG87_RS04870 (1005130) 1005130..1007364 + 2235 WP_000226815.1 GTP pyrophosphokinase -
OEG87_RS04875 (1007442) 1007442..1007690 + 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OEG87_RS04880 (1007690) 1007690..1008025 + 336 WP_000254745.1 endoribonuclease MazF Toxin
OEG87_RS04885 (1008096) 1008096..1008887 + 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
OEG87_RS04890 (1009115) 1009115..1010752 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
OEG87_RS04895 (1010840) 1010840..1012138 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12158.08 Da        Isoelectric Point: 8.4777

>T260046 WP_000254745.1 NZ_CP106924:1007690-1008025 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPYTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT260046 WP_000581937.1 NZ_CP106924:1007442-1007690 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYM3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LMB4

References