Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 869852..870506 Replicon chromosome
Accession NZ_CP106924
Organism Escherichia coli strain MFDS1016424

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag OEG87_RS04255 Protein ID WP_000244777.1
Coordinates 870099..870506 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag OEG87_RS04250 Protein ID WP_000354046.1
Coordinates 869852..870118 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG87_RS04230 (866140) 866140..866451 + 312 WP_134694384.1 N(4)-acetylcytidine aminohydrolase -
OEG87_RS04235 (866615) 866615..867274 + 660 WP_000250274.1 hemolysin III family protein -
OEG87_RS04240 (867397) 867397..868376 - 980 Protein_831 IS110-like element IS621 family transposase -
OEG87_RS04245 (868629) 868629..869609 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
OEG87_RS04250 (869852) 869852..870118 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
OEG87_RS04255 (870099) 870099..870506 + 408 WP_000244777.1 protein YgfX Toxin
OEG87_RS04260 (870546) 870546..871067 - 522 WP_001055874.1 flavodoxin FldB -
OEG87_RS04265 (871179) 871179..872075 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
OEG87_RS04270 (872100) 872100..872810 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OEG87_RS04275 (872816) 872816..874549 + 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T260045 WP_000244777.1 NZ_CP106924:870099-870506 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT260045 WP_000354046.1 NZ_CP106924:869852-870118 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References