Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 304899..305699 Replicon chromosome
Accession NZ_CP106924
Organism Escherichia coli strain MFDS1016424

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag OEG87_RS01415 Protein ID WP_000342451.1
Coordinates 305172..305699 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag OEG87_RS01410 Protein ID WP_001277108.1
Coordinates 304899..305165 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG87_RS01390 (300557) 300557..301225 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
OEG87_RS01395 (301218) 301218..302276 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
OEG87_RS01400 (302520) 302520..303374 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
OEG87_RS01405 (303646) 303646..304749 + 1104 WP_001350438.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
OEG87_RS01410 (304899) 304899..305165 + 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
OEG87_RS01415 (305172) 305172..305699 + 528 WP_000342451.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
OEG87_RS01420 (305696) 305696..306079 - 384 WP_000778795.1 aspartate 1-decarboxylase autocleavage activator PanM -
OEG87_RS01425 (306503) 306503..307612 + 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
OEG87_RS01430 (307660) 307660..308586 + 927 WP_000003004.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
OEG87_RS01435 (308583) 308583..309860 + 1278 WP_000803798.1 branched chain amino acid ABC transporter permease LivM -
OEG87_RS01440 (309857) 309857..310624 + 768 WP_000082110.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19749.73 Da        Isoelectric Point: 7.3232

>T260043 WP_000342451.1 NZ_CP106924:305172-305699 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAELPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT260043 WP_001277108.1 NZ_CP106924:304899-305165 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References