Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 249..712 Replicon plasmid pJD1
Accession NZ_CP106922
Organism Neisseria gonorrhoeae strain 10272

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag NDL74_RS11740 Protein ID WP_003690225.1
Coordinates 434..712 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag NDL74_RS11735 Protein ID WP_003690223.1
Coordinates 249..434 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDL74_RS11730 (NDL74_11730) 1..246 + 246 WP_003690221.1 hypothetical protein -
NDL74_RS11735 (NDL74_11735) 249..434 + 186 WP_003690223.1 DUF5397 family protein Antitoxin
NDL74_RS11740 (NDL74_11740) 434..712 + 279 WP_003690225.1 endoribonuclease VapD Toxin
NDL74_RS11745 (NDL74_11745) 690..944 - 255 WP_003690227.1 Cryptic plasmid protein A -
NDL74_RS11750 (NDL74_11750) 991..1632 - 642 WP_003690229.1 MbeB family mobilization protein -
NDL74_RS11755 (NDL74_11755) 1716..2345 - 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
NDL74_RS11760 (NDL74_11760) 2330..2710 - 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -
NDL74_RS11765 (NDL74_11765) 2776..3000 + 225 WP_025455920.1 hypothetical protein -
NDL74_RS11770 (NDL74_11770) 3083..3952 + 870 WP_003690219.1 replication initiation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4194 4194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T260042 WP_003690225.1 NZ_CP106922:434-712 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT260042 WP_003690223.1 NZ_CP106922:249-434 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References