Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 656612..657267 Replicon chromosome
Accession NZ_CP106921
Organism Neisseria gonorrhoeae strain 10272

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NDL74_RS03515 Protein ID WP_003691083.1
Coordinates 656848..657267 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NDL74_RS03510 Protein ID WP_003688410.1
Coordinates 656612..656848 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDL74_RS03480 (NDL74_03480) 651747..652034 + 288 WP_003688407.1 hypothetical protein -
NDL74_RS03485 (NDL74_03485) 652106..653272 + 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
NDL74_RS03490 (NDL74_03490) 653283..654173 + 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
NDL74_RS03495 (NDL74_03495) 654556..654942 - 387 Protein_683 IS110 family transposase -
NDL74_RS03500 (NDL74_03500) 655292..655582 + 291 WP_047917062.1 helix-turn-helix domain-containing protein -
NDL74_RS03505 (NDL74_03505) 655587..656165 + 579 WP_003697246.1 IS3 family transposase -
NDL74_RS03510 (NDL74_03510) 656612..656848 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NDL74_RS03515 (NDL74_03515) 656848..657267 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NDL74_RS03520 (NDL74_03520) 657416..658870 - 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NDL74_RS03525 (NDL74_03525) 658867..659568 - 702 WP_003688414.1 lactate utilization protein C -
NDL74_RS03530 (NDL74_03530) 659565..660344 - 780 WP_003688416.1 (Fe-S)-binding protein -
NDL74_RS03535 (NDL74_03535) 660492..662033 + 1542 WP_003691084.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T260040 WP_003691083.1 NZ_CP106921:656848-657267 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT260040 WP_003688410.1 NZ_CP106921:656612-656848 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References