Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta(toxin) |
| Location | 22758..24409 | Replicon | plasmid pConjugative |
| Accession | NZ_CP106919 | ||
| Organism | Neisseria gonorrhoeae strain 9071 | ||
Toxin (Protein)
| Gene name | ng_zeta1 | Uniprot ID | D5K9G7 |
| Locus tag | ND436_RS12350 | Protein ID | WP_003701905.1 |
| Coordinates | 22758..23963 (+) | Length | 402 a.a. |
Antitoxin (Protein)
| Gene name | ng_epsilon1 | Uniprot ID | D5K9G8 |
| Locus tag | ND436_RS12355 | Protein ID | WP_003701903.1 |
| Coordinates | 23978..24409 (+) | Length | 144 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ND436_RS12315 (ND436_012315) | 18400..18714 | + | 315 | WP_082295984.1 | hypothetical protein | - |
| ND436_RS12320 (ND436_012320) | 18728..19069 | + | 342 | WP_013085576.1 | hypothetical protein | - |
| ND436_RS12325 (ND436_012325) | 19073..19969 | + | 897 | WP_003701917.1 | hypothetical protein | - |
| ND436_RS12330 (ND436_012330) | 20121..20594 | - | 474 | WP_206692149.1 | hypothetical protein | - |
| ND436_RS12335 (ND436_012335) | 21079..21327 | + | 249 | WP_014580056.1 | hypothetical protein | - |
| ND436_RS12340 (ND436_012340) | 21324..22532 | + | 1209 | WP_014580057.1 | zeta toxin family protein | - |
| ND436_RS12345 (ND436_012345) | 22566..22751 | + | 186 | WP_014580058.1 | hypothetical protein | - |
| ND436_RS12350 (ND436_012350) | 22758..23963 | + | 1206 | WP_003701905.1 | toxin | Toxin |
| ND436_RS12355 (ND436_012355) | 23978..24409 | + | 432 | WP_003701903.1 | hypothetical protein | Antitoxin |
| ND436_RS12360 (ND436_012360) | 24461..25015 | + | 555 | WP_003701901.1 | recombinase family protein | - |
| ND436_RS12365 (ND436_012365) | 25125..25415 | - | 291 | WP_003701899.1 | virulence factor | - |
| ND436_RS12370 (ND436_012370) | 25518..26117 | - | 600 | WP_003701898.1 | TrbN protein | - |
| ND436_RS12375 (ND436_012375) | 26117..26689 | - | 573 | WP_014580059.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| ND436_RS12380 (ND436_012380) | 26682..28289 | - | 1608 | WP_228547153.1 | P-type conjugative transfer protein TrbL | - |
| ND436_RS12385 (ND436_012385) | 28524..29300 | - | 777 | WP_003701891.1 | P-type conjugative transfer protein TrbJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..39054 | 39054 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 402 a.a. Molecular weight: 44675.53 Da Isoelectric Point: 7.7756
>T260039 WP_003701905.1 NZ_CP106919:22758-23963 [Neisseria gonorrhoeae]
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R
Download Length: 1206 bp
Antitoxin
Download Length: 144 a.a. Molecular weight: 15927.05 Da Isoelectric Point: 4.4211
>AT260039 WP_003701903.1 NZ_CP106919:23978-24409 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
Download Length: 432 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|