Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 103761..104671 Replicon plasmid unnamed1
Accession NZ_CP106913
Organism Klebsiella pneumoniae strain BSIKPN-9

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag OE131_RS27645 Protein ID WP_004026354.1
Coordinates 103761..104231 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag OE131_RS27650 Protein ID WP_004026357.1
Coordinates 104228..104671 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OE131_RS27620 (OE131_27620) 99173..99571 - 399 WP_004212796.1 H-NS family nucleoid-associated regulatory protein -
OE131_RS27625 (OE131_27625) 99908..100402 - 495 WP_004212794.1 thermonuclease family protein -
OE131_RS27630 (OE131_27630) 100580..100846 + 267 WP_223175074.1 DUF1173 family protein -
OE131_RS27635 (OE131_27635) 100879..101529 + 651 WP_068893702.1 DUF1173 family protein -
OE131_RS27645 (OE131_27645) 103761..104231 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
OE131_RS27650 (OE131_27650) 104228..104671 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
OE131_RS27655 (OE131_27655) 104772..105275 - 504 Protein_111 DUF4113 domain-containing protein -
OE131_RS27660 (OE131_27660) 105481..106461 - 981 WP_000019473.1 IS5-like element ISKpn26 family transposase -
OE131_RS27665 (OE131_27665) 106527..107834 + 1308 Protein_113 FepA family TonB-dependent siderophore receptor -
OE131_RS27670 (OE131_27670) 107896..108117 + 222 WP_004213615.1 hypothetical protein -
OE131_RS27675 (OE131_27675) 108260..109162 - 903 WP_004213613.1 DMT family inner membrane transporter PEG344 -
OE131_RS27680 (OE131_27680) 109235..109636 - 402 WP_214588034.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..216672 216672
- inside IScluster/Tn - - 97722..106461 8739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T260026 WP_004026354.1 NZ_CP106913:c104231-103761 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT260026 WP_004026357.1 NZ_CP106913:c104671-104228 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References