Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4916995..4917511 Replicon chromosome
Accession NZ_CP106912
Organism Klebsiella pneumoniae strain BSIKPN-9

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag OE131_RS24430 Protein ID WP_002886902.1
Coordinates 4916995..4917279 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OE131_RS24435 Protein ID WP_002886901.1
Coordinates 4917269..4917511 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OE131_RS24405 (OE131_24405) 4912479..4912742 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
OE131_RS24410 (OE131_24410) 4912872..4913045 + 174 WP_002886906.1 hypothetical protein -
OE131_RS24415 (OE131_24415) 4913048..4913791 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OE131_RS24420 (OE131_24420) 4914148..4916286 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
OE131_RS24425 (OE131_24425) 4916527..4916991 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OE131_RS24430 (OE131_24430) 4916995..4917279 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OE131_RS24435 (OE131_24435) 4917269..4917511 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OE131_RS24440 (OE131_24440) 4917589..4919499 - 1911 WP_004152270.1 PRD domain-containing protein -
OE131_RS24445 (OE131_24445) 4919522..4920676 - 1155 WP_002886900.1 lactonase family protein -
OE131_RS24450 (OE131_24450) 4920742..4921482 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T260022 WP_002886902.1 NZ_CP106912:c4917279-4916995 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT260022 WP_002886901.1 NZ_CP106912:c4917511-4917269 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References